Publications
Giraud A, Dinomais M, Garel P, Chevin M, Thébault G, Renaud C, Presles É, Raia-Barjat T, Sébire G, Chabrier S. Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke. Dev Med Child Neurol. 2023 Jan
Chevin M, Chabrier S, Allard MJ, Sébire G. Necroptosis Blockade Potentiates the Neuroprotective Effect of Hypothermia in Neonatal Hypoxic-Ischemic Encephalopathy. Biomedicines. 2022 Nov
Schiller K, Berrahmoune S, Dassi C, Corriveau I, Ayash TA, Osterman B, Poulin C, Shevell MI, Simard-Tremblay E, Sébire G, Myers KA. Randomized placebo-controlled crossover trial of memantine in children with epileptic encephalopathy. Brain. 2022 Oct
Ayash TA, Vancolen SY, Segura M, Allard MJ, Sébire G. Protective Effects of Interleukin-1 Blockade on Group B Streptococcus-Induced Chorioamnionitis and Subsequent Neurobehavioral Impairments of the Offspring. Front Endocrinol (Lausanne). 2022 Jul
Vancolen S, Ayash T, Segura M, Allard MJ, Robaire B, Sébire G. Androgens Upregulate Pathogen-Induced Placental Innate Immune Response. Int J Mol Sci. 2022 Apr
Ow N, Karp A, Ogeil J, Dilenge ME, Sébire G, Dahan-Oliel N, Kuspinar A, Mayo NE. Quality of life in pediatric-onset multiple sclerosis: Different disease course, different impact, different measurement approach needed. Mult Scler Relat Disord. 2022 Jul
Raia-Barjat T, Digonnet M, Giraud A, Ayash T, Vancolen S, Benharouga M, Chauleur C, Alfaidy N, Sébire G. Animal Models of Chorioamnionitis: Considerations for Translational Medicine. Biomedicines. 2022 Mar
Ayash TA, Vancolen SY, Allard MJ, Sébire G. C-section of Preclinical Animal Model of Chorioamnionitis Triggered by Group B Streptococcus (GBS). J Vis Exp. 2021 Dec
Silva ALM, Silva ECO, Botelho RM, Tenorio LPG, Marques ALX, Rodrigues IBAC, Almeida LIM, Sousa AKA, Pires KSN, Tanabe ISB, Allard MJ, Sébire G, Souza ST, Fonseca EJS, Borbely KSC, Borbely AU. Uvaol Prevents Group B Streptococcus-Induced Trophoblast Cells Inflammation and Possible Endothelial Dysfunction. Front Physiol. 2021 Dec
Al Amrani F, Sébire G, Chen MF, Wintermark P, Saint-Martin C. Distinctive Neuroimaging Pattern in Term Newborns With Neonatal Placental Encephalopathy: A Case Series. Pediatr Neurol. 2022 Jan
Fadda G, Alves CA, O’Mahony J, Castro DA, Yeh EA, Marrie RA, Arnold DL, Waters P, Bar-Or A, Vossough A, Banwell B; Canadian Pediatric Demyelinating Disease Study Group. Comparison of Spinal Cord Magnetic Resonance Imaging Features Among Children With Acquired Demyelinating Syndromes. JAMA Netw Open. 2021 Oct
Ashour M, Fortin O, Parent L, Sébire G, Saint-Martin C, Poulin C, Dudley R. Hirayama Disease in a Patient with a History of Late-Onset Symptomatic Vein of Galen Aneurysmal Malformation. Pediatr Neurosurg. 2021
Chevin M, Sébire G. Necroptosis in ALS: a hot topic in-progress. Cell Death Discov. 2021 Apr
Chevin M, Sébire G, Deltenre P, Kadhim H. Necroptotic neuronal cell death in amyotrophic lateral sclerosis: A relevant hypothesis with potential therapeutic implication?. Med Hypotheses. 2020 Nov
Nakhaipour HR, Vudumula U, Khurana V, Sébire G, Mah JK, Pohl D, Schecter R, Adlard N. Cost-effectiveness of fingolimod versus interferon-β1a for the treatment of pediatric-onset multiple sclerosis in Canada. J Med Econ. 2020 Dec
Yea C, Bitnun A, Branson HM, Ciftci-Kavaklioglu B, Rafay MF, Fortin O, Moresoli P, Sébire G, Srour M, Decaluwe H, Marois L, Pelletier F, Barton M, Nouri MN, Brophy J, Venkateswaran S, Pohl D, Selby K, Jones K, Robinson J, Mineyko A, Licht C, Ertl-Wagner B, Yeh EA. Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study. Lancet Child Adolesc Health. 2020 Nov
Pelletier F, Perrier S, Cayami FK, Mirchi A, Saikali S, Tran LT, Ulrick N, Guerrero K, Rampakakis E, van Spaendonk RML, Naidu S, Pohl D, Gibson WT, Demos M, Goizet C, Tejera-Martin I, Potic A, Fogel BL, Brais B, Sylvain M, Sébire G, Lourenço CM, Bonkowsky JL, Catsman-Berrevoets C, Pinto PS, Tirupathi S, Strømme P, de Grauw T, Gieruszczak-Bialek D, Krägeloh-Mann I, Mierzewska H, Philippi H, Rankin J, Atik T, Banwell B, Benko WS, Blaschek A, Bley A, Boltshauser E, Bratkovic D, Brozova K, Cimas I, Clough C, Corenblum B, Dinopoulos A, Dolan G, Faletra F, Fernandez R, Fletcher J, Garcia Garcia ME, Gasparini P, Gburek-Augustat J, Gonzalez Moron D, Hamati A, Harting I, Hertzberg C, Hill A, Hobson GM, Innes AM, Kauffman M, Kirwin SM, Kluger G, Kolditz P, Kotzaeridou U, La Piana R, Liston E, McClintock W, McEntagart M, McKenzie F, Melançon S, Misbahuddin A, Suri M, Monton FI, Moutton S, Murphy RPJ, Nickel M, Onay H, Orcesi S, Özkınay F, Patzer S, Pedro H, Pekic S, Pineda Marfa M, Pizzino A, Plecko B, Poll-The BT, Popovic V, Rating D, Rioux MF, Rodriguez Espinosa N, Ronan A, Ostergaard JR, Rossignol E, Sanchez-Carpintero R, Schossig A, Senbil N, Sønderberg Roos LK, Stevens CA, Synofzik M, Sztriha L, et al. Endocrine and Growth Abnormalities in 4H Leukodystrophy Caused by Variants in POLR3A, POLR3B, and POLR1C. J Clin Endocrinol Metab. 2021 Jan
Giraud A, Chaux R, Allard MJ, Celle M, Teyssier G, Roche F, Chapelle C, Chabrier S, Sébire G, Patural H. Perinatal inflammation is associated with social and motor impairments in preterm children without severe neonatal brain injury. Eur J Paediatr Neurol. 2020 Sep
Dermer E, Spahr A, Tran LT, Mirchi A, Pelletier F, Guerrero K, Ahmed S, Brais B, Braverman N, Buhas D, Chandratre S, Chenier S, Chrestian N, Desmeules M, Dilenge ME, Laflamme J, Larbrisseau A, Legault G, Lim KY, Maftei C, Major P, Malvey-Dorn E, Marois P, Mitchell J, Nadeau A, Osterman B, Paradis I, Pohl D, Reggin J, Riou E, Roedde G, Rossignol E, Sébire G, Shevell M, Srour M, Sylvain M, Tarnopolsky M, Venkateswaran S, Sullivan M, Bernard G. Stress in Parents of Children With Genetically Determined Leukoencephalopathies: A Pilot Study. J Child Neurol. 2020 Nov
Giraud A, Allard MJ, Segura M, Roche F, Patural H, Sébire G. Ampicillin Treatment Increases Placental Interleukin-1 Beta Concentration and Polymorphonuclear Infiltration in Group B Streptococcus-Induced Chorioamnionitis: A Preclinical Study. Neonatology. 2020
Chevin M, Chelabi K, Chabrier S, Sébire G. Added value of interleukin-1 blockade to hypothermia in the treatment of neonatal encephalopathy. Am J Obstet Gynecol. 2020 Sep
Chevin M, Chabrier S, Dinomais M, Bedell BJ, Sébire G. Benefits of hypothermia in neonatal arterial ischemic strokes: A preclinical study. Int J Dev Neurosci. 2020 Jun
Tsai MH, Muir AM, Wang WJ, Kang YN, Yang KC, Chao NH, Wu MF, Chang YC, Porter BE, Jansen LA, Sébire G, Deconinck N, Fan WL, Su SC, Chung WH, Almanza Fuerte EP, Mehaffey MG; University of Washington Center for Mendelian Genomics; Ng CC, Chan CK, Lim KS, Leventer RJ, Lockhart PJ, Riney K, Damiano JA, Hildebrand MS, Mirzaa GM, Dobyns WB, Berkovic SF, Scheffer IE, Tsai JW, Mefford HC. Pathogenic Variants in CEP85L Cause Sporadic and Familial Posterior Predominant Lissencephaly. Neuron. 2020 Apr
Chilton I, Okur V, Vitiello G, Selicorni A, Mariani M, Goldenberg A, Husson T, Campion D, Lichtenbelt KD, van Gassen K, Steinraths M, Rice J, Roeder ER, Littlejohn RO, Srour M, Sébire G, Accogli A, Héron D, Heide S, Nava C, Depienne C, Larson A, Niyazov D, Azage M, Hoganson G, Burton J, Rush ET, Jenkins JL, Saunders CJ, Thiffault I, Alaimo JT, Fleischer J, Groepper D, Gripp KW, Chung WK. De novo heterozygous missense and loss-of-function variants in CDC42BPB are associated with a neurodevelopmental phenotype. Am J Med Genet A. 2020 May
Goeggel Simonetti B, Rafay MF, Chung M, Lo WD, Beslow LA, Billinghurst LL, Fox CK, Pagnamenta A, Steinlin M, Mackay MT; IPSS Study Group. Comparative study of posterior and anterior circulation stroke in childhood: Results from the International Pediatric Stroke Study. Neurology. 2020 Jan
Alawadhi A, Saint-Martin C, Sabapathy C, Sébire G, Shevell M. Lateral Medullary Syndrome Due to Left Vertebral Artery Occlusion in a Boy Postflexion Neck Injury. Child Neurol Open. 2019 Aug
Chabrier S, Sébire G. Perinatal inflammation and placental programming of neonatal stroke. Dev Med Child Neurol. 2020 Apr
Chabrier S, Pouyfaucon M, Chatelin A, Bleyenheuft Y, Fluss J, Gautheron V, Newman CJ, Sébire G, Van Bogaert P, Vuillerot C, Brochard S, Dinomais M. From congenial paralysis to post-early brain injury developmental condition: Where does cerebral palsy actually stand?. Ann Phys Rehabil Med. 2020 Oct
Botelho RM, Tenorio LPG, Silva ALM, Tanabe ELL, Pires KSN, Gonçalves CM, Santos JC, Marques ALX, Allard MJ, Bergeron JD, Sébire G, Silva ECO, Souza ST, Fonseca EJS, Borbely AU, Borbely KSC. Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment. Biochim Biophys Acta Gen Subj. 2019 Sep
Allard MJ, Giraud A, Segura M, Sébire G. Sex-specific maternofetal innate immune responses triggered by group B Streptococci. Sci Rep. 2019 Jun
Allard MJ, Brochu ME, Bergeron JD, Segura M, Sébire G. Causal role of group B Streptococcus-induced acute chorioamnionitis in intrauterine growth retardation and cerebral palsy-like impairments. J Dev Orig Health Dis. 2019 Jan
Allard MJ, Brochu ME, Bergeron JD, Sébire G. Hyperactive behavior in female rats in utero-exposed to group B Streptococcus-induced inflammation. Int J Dev Neurosci. 2018 Oct
Chevin M, Guiraut C, Sébire G. Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns. J Neuroinflammation. 2018 Jul
Alawadhi A, Saint-Martin C, Bhanji F, Srour M, Atkinson J, Sébire G. Acute Hemorrhagic Encephalitis Responding to Combined Decompressive Craniectomy, Intravenous Immunoglobulin, and Corticosteroid Therapies: Association with Novel RANBP2 Variant. Front Neurol. 2018 Mar
Giraud A, Guiraut C, Chevin M, Chabrier S, Sébire G. Role of Perinatal Inflammation in Neonatal Arterial Ischemic Stroke. Front Neurol. 2017 Nov
Al Amrani F, Dudley R, Bello-Espinosa LE, Rosenblatt B, Srour M, Sébire G. Intravenous Immunoglobulin as a Treatment for Intractable Epilepsy Secondary to Focal Cortical Dysplasia: A Meta-analysis. Pediatr Neurol. 2017 Nov
Allard MJ, Bergeron JD, Baharnoori M, Srivastava LK, Fortier LC, Poyart C, Sébire G. A sexually dichotomous, autistic-like phenotype is induced by Group B Streptococcus maternofetal immune activation. Autism Res. 2017 Feb
Sahly A, Gauquelin L, Sébire G. Rapid Resolution of Enterovirus 71-Associated Opsoclonus Myoclonus Syndrome on Intravenous Immunoglobulin. Child Neurol Open. 2017 Sep
Guiraut C, Cauchon N, Lepage M, Sébire G. Perinatal Arterial Ischemic Stroke Is Associated to Materno-Fetal Immune Activation and Intracranial Arteritis. Int J Mol Sci. 2016 Nov
Bergeron J, Gerges N, Guiraut C, Grbic D, Allard MJ, Fortier LC, Vaillancourt C, Sébire G. Activation of the IL-1β/CXCL1/MMP-10 axis in chorioamnionitis induced by inactivated Group B Streptococcus. Placenta. 2016 Nov
Chevin M, Guiraut C, Maurice-Gelinas C, Deslauriers J, Grignon S, Sébire G. Neuroprotective effects of hypothermia in inflammatory-sensitized hypoxic-ischemic encephalopathy. Int J Dev Neurosci. 2016 Dec
Kadhim H, Deltenre P, Martin JJ, Sébire G. In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms. Med Hypotheses. 2016 Jan
Girard S, Sebire G. Transplacental Transfer of Interleukin-1 Receptor Agonist and Antagonist Following Maternal Immune Activation. Am J Reprod Immunol. 2016 Jan
Savard A, Brochu ME, Chevin M, Guiraut C, Grbic D, Sébire G. Neuronal self-injury mediated by IL-1β and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia. J Neuroinflammation. 2015 May
Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, Sébire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol. 2015 Feb
Beaudoin AJ, Sébire G, Couture M. Parent training interventions for toddlers with autism spectrum disorder. Autism Res Treat. 2014
Bergeron JD, Deslauriers J, Grignon S, Fortier LC, Lepage M, Stroh T, Poyart C, Sébire G. White matter injury and autistic-like behavior predominantly affecting male rat offspring exposed to group B streptococcal maternal inflammation. Dev Neurosci. 2013
Savard A, Lavoie K, Brochu ME, Grbic D, Lepage M, Gris D, Sebire G. Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy. J Neuroinflammation. 2013 Sep
Girard S, Sébire H, Brochu ME, Briota S, Sarret P, Sébire G. Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries. Brain Behav Immun. 2012 Nov
Kadhim H, Deltenre P, Segers V, Sébire G. Selective expression of a neuromodulatory cytokine (IL-2) in specific brainstem neurovegetative centers: a possible final common neuro-molecular pathway in dying patients. Med Hypotheses. 2012 Jun
Girard S, Tremblay L, Lepage M, Sebire G. Early detection of placental inflammation by MRI enabling protection by clinically relevant IL-1Ra administration. Am J Obstet Gynecol. 2012 Apr
Brochu ME, Girard S, Lavoie K, Sébire G. Developmental regulation of the neuroinflammatory responses to LPS and/or hypoxia-ischemia between preterm and term neonates: An experimental study. J Neuroinflammation. 2011 May 20
Morin MP, Patenaude Y, Sinsky AB, Banwell B, Sébire G. Solitary tumefactive demyelinating lesions in children. J Child Neurol. 2011 Aug
Girard S, Sébire G, Kadhim H. Proinflammatory orientation of the interleukin 1 system and downstream induction of matrix metalloproteinase 9 in the pathophysiology of human perinatal white matter damage. J Neuropathol Exp Neurol. 2010 Nov
Kadhim H, Deltenre P, De Prez C, Sébire G. Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome. Neurosci Lett. 2010 Aug 16
Sébire G. In search of lost time from “Demonic Possession” to anti-N-methyl-D-aspartate receptor encephalitis. Ann Neurol. 2010 Jan
Girard S, Tremblay L, Lepage M, Sébire G. IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation. J Immunol. 2010 Apr 1
Roy M, Girard S, Larouche A, Kadhim H, Sébire G. TNF-alpha system response in a rat model of very preterm brain injuries induced by lipopolysaccharide and/or hypoxia-ischemia. Am J Obstet Gynecol. 2009 Nov
Amlie-Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, Lerner NB, DeVeber G, Fullerton HJ; International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study. Circulation. 2009 Mar
Girard S, Kadhim H, Roy M, Lavoie K, Brochu ME, Larouche A, Sébire G. Role of perinatal inflammation in cerebral palsy. Pediatr Neurol. 2009 Mar
Braun KP, Bulder MM, Chabrier S, Kirkham FJ, Uiterwaal CS, Tardieu M, Sébire G. The course and outcome of unilateral intracranial arteriopathy in 79 children with ischaemic stroke. Brain. 2009 Feb
Girard S, Kadhim H, Beaudet N, Sarret P, Sébire G. Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: a novel animal model for cerebral palsy in very premature infants. Neuroscience. 2009 Jan
Girard S, Larouche A, Kadhim H, Rola-Pleszczynski M, Gobeil F, Sébire G. Lipopolysaccharide and hypoxia/ischemia induced IL-2 expression by microglia in neonatal brain. Neuroreport. 2008 Jul
Girard S, Kadhim H, Larouche A, Roy M, Gobeil F, Sébire G. Pro-inflammatory disequilibrium of the IL-1 beta/IL-1ra ratio in an experimental model of perinatal brain damages induced by lipopolysaccharide and hypoxia-ischemia. Cytokine. 2008 Jul
Kadhim HJ, Duchateau J, Sébire G. Cytokines and brain injury: invited review. J Intensive Care Med. 2008 Jul-Aug
Amlie-Lefond C, Sébire G, Fullerton HJ. Recent developments in childhood arterial ischaemic stroke. Lancet Neurol. 2008 May
Kadhim H, Khalifa M, Deltenre P, Casimir G, Sébire G. Molecular mechanisms of cell death in periventricular leukomalacia. Neurology. 2006 Jul
Sébire G. Transient cerebral arteriopathy in childhood. Lancet. 2006 Jul
Larouche A, Roy M, Kadhim H, Tsanaclis AM, Fortin D, Sébire G. Neuronal injuries induced by perinatal hypoxic-ischemic insults are potentiated by prenatal exposure to lipopolysaccharide: animal model for perinatally acquired encephalopathy. Dev Neurosci. 2005 Mar-Aug
Sébire G, Tabarki B, Saunders DE, Leroy I, Liesner R, Saint-Martin C, Husson B, Williams AN, Wade A, Kirkham FJ. Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome. Brain. 2005 Mar
Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA. Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. Nat Genet. 2004 Jan
Kadhim H, Kahn A, Sébire G. Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome? Neurology. 2003 Nov
Bonnier C, Nassogne MC, Saint-Martin C, Mesples B, Kadhim H, Sébire G. Neuroimaging of intraparenchymal lesions predicts outcome in shaken baby syndrome. Pediatrics. 2003 Oct
Kadhim H, Tabarki B, De Prez C, Sébire G. Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy? Acta Neuropathol. 2003 Mar
Husson B, Rodesch G, Lasjaunias P, Tardieu M, Sébire G. Magnetic resonance angiography in childhood arterial brain infarcts: a comparative study with contrast angiography. Stroke. 2002 May
Kadhim H, Tabarki B, De Prez C, Rona AM, Sébire G. Interleukin-2 in the pathogenesis of perinatal white matter damage. Neurology. 2002 Apr
Kadhim H, Tabarki B, Verellen G, De Prez C, Rona AM, Sébire G. Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology. 2001 May
Kadhim H, Proaño PG, Saint Martin C, Boscherini D, Clapuyt P, Godfraind C, Duprez T, Raftopoulos C, Sébire G. Spinal neurenteric cyst presenting in infancy with chronic fever and acute myelopathy. Neurology. 2000 May
Sébire G, Meyer L, Chabrier S. Varicella as a risk factor for cerebral infarction in childhood: a case-control study. Ann Neurol. 1999 May
Thébaud B, Husson B, Navelet Y, Huault G, Landrieu P, Devictor D, Sebire G. Haemorrhagic shock and encephalopathy syndrome: neurological course and predictors of outcome. Intensive Care Med. 1999 Mar
Delanoe C, Sebire G, Landrieu P, Huault G, Metral S. Acute inflammatory demyelinating polyradiculopathy in children: clinical and electrodiagnostic studies. Ann Neurol. 1998 Sep
Sébire G, Goutières F, Tardieu M, Landrieu P, Aicardi J. Extensive macrogyri or no visible gyri: distinct clinical, electroencephalographic, and genetic features according to different imaging patterns. Neurology. 1995 Jun
Héry C, Sébire G, Peudenier S, Tardieu M. Adhesion to human neurons and astrocytes of monocytes: the role of interaction of CR3 and ICAM-1 and modulation by cytokines. J Neuroimmunol. 1995 Mar
Sébire G, Emilie D, Wallon C, Héry C, Devergne O, Delfraissy JF, Galanaud P, Tardieu M. In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells. J Immunol. 1993 Feb
Sébire G, Devictor D, Huault G, Aicardi J, Landrieu P, Tardieu M. Coma associated with intense bursts of abnormal movements and long-lasting cognitive disturbances: an acute encephalopathy of obscure origin. J Pediatr. 1992 Dec
Sebire lab 